At the ripe age of 73, Imogene Deal McGregor has a penchant for following her own instincts, as well as more grit and spunk than her hypochondriac son, Billy McGregor, and Billy’s impulsive partner, Jackson, can handle. The boys take Imogene to New Orleans with their devilishly handsome English bulldog Goose, hoping to visit friends and attend a second line parade, but moments after arriving in the French Quarter, they find their friend Glenway Gilbert murdered in his art gallery.
Immediately, Imogene and the boys run into a temperamental and ethically-challenged lieutenant who appears hell-bent on neglecting the crime, compelling them to seek answers themselves. As they delve into Glenway Gilbert’s murder, Imogene and the boys realize the deceased artist was surrounded by suspicious friends and lovers. With Goose the bulldog by their side, Jackson and Billy seek answers among old friends and new enemies, while Imogene follows her own ideas on the case. But the sooner they solve the murder, the sooner they can get back to catching beads and eating pralines.